Motif ID: HOX{A5,B5}.p2

Z-value: 1.787


Transcription factors associated with HOX{A5,B5}.p2:

Gene SymbolEntrez IDGene Name
HOXA5 3202 homeobox A5
HOXB5 3215 homeobox B5

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HOXB5chr17_-_44026042-0.332.2e-01Click!
HOXA5chr7_-_27149750-0.116.7e-01Click!


Activity profile for motif HOX{A5,B5}.p2.

activity profile for motif HOX{A5,B5}.p2


Sorted Z-values histogram for motif HOX{A5,B5}.p2

Sorted Z-values for motif HOX{A5,B5}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HOX{A5,B5}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_-_112010233 2.809 NM_001012993
C9orf152
chromosome 9 open reading frame 152
chrX_+_100220491 2.650 NM_021637
TMEM35
transmembrane protein 35
chr7_+_5289079 2.569 NM_001040661
NM_153247
SLC29A4

solute carrier family 29 (nucleoside transporters), member 4

chr1_-_12599934 2.008 NM_004753
DHRS3
dehydrogenase/reductase (SDR family) member 3
chrX_+_51562894 1.788 NM_001005332
MAGED1
melanoma antigen family D, 1
chrX_+_128700605 1.765 NM_003399
XPNPEP2
X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound
chr17_-_44249379 1.588 NM_001130918
TTLL6
tubulin tyrosine ligase-like family, member 6
chr13_+_113574925 1.523 NM_001143945
GAS6
growth arrest-specific 6
chr16_+_56219802 1.373 NM_001145771
NM_001145772
NM_001145773
NM_201524
NM_201525
GPR56




G protein-coupled receptor 56




chr12_+_53241365 1.372 NM_001165975
PDE1B
phosphodiesterase 1B, calmodulin-dependent
chr11_-_117600918 1.358 NM_001098526
AMICA1
adhesion molecule, interacts with CXADR antigen 1
chr1_-_41259973 1.343 NM_001168247
NM_144990
SLFNL1

schlafen-like 1

chr15_-_72804763 1.308 NM_000499
CYP1A1
cytochrome P450, family 1, subfamily A, polypeptide 1
chrX_-_99778340 1.286 NM_003270
TSPAN6
tetraspanin 6
chr19_-_53187151 1.278 NM_001128326
BSPH1
binder of sperm protein homolog 1
chr1_-_154041393 1.251 GON4L
gon-4-like (C. elegans)
chr6_+_31651319 1.248 NM_000594
TNF
tumor necrosis factor
chr17_+_6620275 1.233 NM_153230
FBXO39
F-box protein 39
chr2_+_113648020 1.190 NM_012455
PSD4
pleckstrin and Sec7 domain containing 4
chr1_+_143326315 1.167 NM_001037675
NBPF10
NBPF9
NBPF8
neuroblastoma breakpoint family, member 10
neuroblastoma breakpoint family, member 9
neuroblastoma breakpoint family, member 8
chr19_-_56549853 1.155 NM_001014763
ETFB
electron-transfer-flavoprotein, beta polypeptide
chr8_-_143830930 1.140 NM_205545
LYPD2
LY6/PLAUR domain containing 2
chr17_-_7036490 1.124


chrX_+_48253007 1.073 NM_203474
NM_203475
PORCN

porcupine homolog (Drosophila)

chr12_+_107433179 1.068 NM_007076
FICD
FIC domain containing
chr16_-_48960186 1.064 NM_001173984
NM_013263
BRD7

bromodomain containing 7

chr1_+_154855709 1.061 NM_021817
HAPLN2
hyaluronan and proteoglycan link protein 2
chr19_-_13925192 1.052 NM_001146254
NM_001146255
PODNL1

podocan-like 1

chr1_+_114323552 1.025 NM_020190
OLFML3
olfactomedin-like 3
chr13_+_28496746 1.006 NM_001033602
MTUS2
microtubule associated tumor suppressor candidate 2
chrX_+_14457340 0.996 NM_001118885
NM_001118886
NM_001171942
NM_002063
GLRA2



glycine receptor, alpha 2



chr22_-_35938298 0.996 NM_001051
SSTR3
somatostatin receptor 3
chr19_-_51236113 0.995 NM_001002923
IGFL4
IGF-like family member 4
chr11_+_118259684 0.992 NM_001716
CXCR5
chemokine (C-X-C motif) receptor 5
chrX_-_104352005 0.969 NM_031274
TEX13A
testis expressed 13A
chr14_+_20568184 0.964 NM_173846
TPPP2
tubulin polymerization-promoting protein family member 2
chr6_-_41114905 0.960 NM_173561
UNC5CL
unc-5 homolog C (C. elegans)-like
chr3_+_9933763 0.949 NM_032732
NM_153460
NM_153461
IL17RC


interleukin 17 receptor C


chr11_-_47330797 0.949 NM_000256
MYBPC3
myosin binding protein C, cardiac
chr9_-_33385265 0.944 AQP7
aquaporin 7
chr1_+_144124547 0.941 NM_145277
NM_202004
NM_213652
NM_213653
HFE2



hemochromatosis type 2 (juvenile)



chr5_+_148766632 0.937 LOC728264
hypothetical LOC728264
chrX_-_107112244 0.928 NM_031273
TEX13B
testis expressed 13B
chr1_+_204484081 0.920 NM_001910
NM_148964
CTSE

cathepsin E

chr2_+_113648036 0.916 PSD4
pleckstrin and Sec7 domain containing 4
chrX_+_46962370 0.915 NM_033018
CDK16
cyclin-dependent kinase 16
chr19_+_51190535 0.910 CCDC61
coiled-coil domain containing 61
chrX_+_7147471 0.905 NM_000351
STS
steroid sulfatase (microsomal), isozyme S
chr1_+_146843980 0.877 NM_001102663
NBPF15
NBPF8
NBPF16
neuroblastoma breakpoint family, member 15
neuroblastoma breakpoint family, member 8
neuroblastoma breakpoint family, member 16
chr1_+_246290586 0.869 NM_001004687
OR2L3
olfactory receptor, family 2, subfamily L, member 3
chr1_+_153846602 0.869 NM_018116
MSTO1
misato homolog 1 (Drosophila)
chr3_-_197023096 0.865 MUC4
mucin 4, cell surface associated
chr5_+_357290 0.864 NM_020731
AHRR
aryl-hydrocarbon receptor repressor
chr4_+_109033868 0.861 NM_001136257
NM_152621
SGMS2

sphingomyelin synthase 2

chr19_+_46207335 0.857 CYP2B6
cytochrome P450, family 2, subfamily B, polypeptide 6
chr17_+_71109734 0.856 MYO15B
myosin XVB pseudogene
chr1_-_120240635 0.851 NM_021794
ADAM30
ADAM metallopeptidase domain 30
chrX_-_57953578 0.836 NM_007156
ZXDA
zinc finger, X-linked, duplicated A
chrX_+_15718494 0.835 NM_005089
ZRSR2
zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2
chr19_+_51190178 0.813 NM_001080402
CCDC61
coiled-coil domain containing 61
chr16_-_2776606 0.804 NM_152891
PRSS33
protease, serine, 33
chr4_-_57382584 0.798 NM_021114
SPINK2
serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
chr12_-_4358968 0.792 NM_020638
FGF23
fibroblast growth factor 23
chr9_-_91302707 0.786 SEMA4D
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
chr6_-_29563657 0.764 NM_052967
MAS1L
MAS1 oncogene-like
chr17_-_35911340 0.762 NM_032865
TNS4
tensin 4
chr1_+_158352143 0.751 NM_000702
ATP1A2
ATPase, Na+/K+ transporting, alpha 2 polypeptide
chr12_-_6668680 0.736 ZNF384
zinc finger protein 384
chrX_-_23955223 0.736 NM_030624
KLHL15
kelch-like 15 (Drosophila)
chr15_+_41597097 0.735 NM_002373
MAP1A
microtubule-associated protein 1A
chr17_+_30498948 0.728 NM_001033576
NM_173167
UNC45B

unc-45 homolog B (C. elegans)

chr12_+_6884157 0.725 NM_001135217
NM_006992
NM_201650
LRRC23


leucine rich repeat containing 23


chrX_+_48265107 0.703 NM_006579
EBP
emopamil binding protein (sterol isomerase)
chrX_+_144136798 0.703 NM_001009614
SPANXN1
SPANX family, member N1
chr1_+_203503214 0.698 TMCC2
transmembrane and coiled-coil domain family 2
chr3_-_46481346 0.694 NM_002343
LTF
lactotransferrin
chrX_-_135166306 0.693 NM_001173516
MAP7D3
MAP7 domain containing 3
chrX_+_102770303 0.692 NM_001006640
TCEAL1
transcription elongation factor A (SII)-like 1
chr8_+_143758875 0.691 NM_005672
PSCA
prostate stem cell antigen
chr11_+_70937113 0.688 NM_005553
KRTAP5-9
keratin associated protein 5-9
chr11_+_36274300 0.687 NM_001160167
PRR5L
proline rich 5 like
chr6_-_24985432 0.687 NM_015864
FAM65B
family with sequence similarity 65, member B
chrX_+_102770547 0.683 NM_001006639
NM_004780
TCEAL1

transcription elongation factor A (SII)-like 1

chrX_+_102498035 0.679 NM_001006612
NM_001006613
NM_001006614
NM_016303
WBP5



WW domain binding protein 5



chrX_-_1291526 0.678 NM_001012288
NM_022148
CRLF2

cytokine receptor-like factor 2

chr9_-_134809816 0.664 NM_000368
NM_001162426
NM_001162427
TSC1


tuberous sclerosis 1


chr19_-_53444733 0.657 NM_001184901
NM_001184903
NM_014959
CARD8


caspase recruitment domain family, member 8


chr9_-_134809774 0.657 TSC1
tuberous sclerosis 1
chr9_-_129752687 0.650 NM_203305
FAM102A
family with sequence similarity 102, member A
chr5_+_17270474 0.645 NM_006317
BASP1
brain abundant, membrane attached signal protein 1
chr6_-_32299757 0.639 NM_004557
NOTCH4
notch 4
chr11_-_6633427 0.636 NM_003737
DCHS1
dachsous 1 (Drosophila)
chrX_+_37777730 0.633 NM_001163334
SYTL5
synaptotagmin-like 5
chr1_+_147006065 0.626 NM_001102663
NBPF15
NBPF8
NBPF16
neuroblastoma breakpoint family, member 15
neuroblastoma breakpoint family, member 8
neuroblastoma breakpoint family, member 16
chr1_-_154215558 0.621 ARHGEF2
Rho/Rac guanine nucleotide exchange factor (GEF) 2
chr3_-_197549588 0.621 TM4SF19
transmembrane 4 L six family member 19
chr12_+_52806103 0.621 LOC400043
hypothetical LOC400043
chr3_-_185025989 0.621 NM_024871
MAP6D1
MAP6 domain containing 1
chr19_-_51168396 0.617 NM_002516
NOVA2
neuro-oncological ventral antigen 2
chrX_-_137777382 0.615 NM_001139502
FGF13
fibroblast growth factor 13
chr3_+_11009436 0.614 SLC6A1
solute carrier family 6 (neurotransmitter transporter, GABA), member 1
chr8_-_143996257 0.612 NM_000498
CYP11B2
cytochrome P450, family 11, subfamily B, polypeptide 2
chrX_-_152863251 0.611 NM_002910
RENBP
renin binding protein
chr7_+_129807467 0.609 NM_001868
CPA1
carboxypeptidase A1 (pancreatic)
chrX_+_148433970 0.604 NM_001171909
CXorf40A
chromosome X open reading frame 40A
chr16_-_65984836 0.603 NM_015964
NM_016140
TPPP3

tubulin polymerization-promoting protein family member 3

chr1_-_245763763 0.599 NM_198074
OR2C3
olfactory receptor, family 2, subfamily C, member 3
chr5_-_1165106 0.598 NM_006598
SLC12A7
solute carrier family 12 (potassium/chloride transporters), member 7
chr19_-_1966628 0.586 NM_017797
BTBD2
BTB (POZ) domain containing 2
chr17_+_7279485 0.586 NM_178518
TMEM102
transmembrane protein 102
chr7_+_1536847 0.584 NM_002360
MAFK
v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)
chr15_-_80611897 0.583 NM_001021
RPS17
ribosomal protein S17
chr1_+_202000906 0.573 NM_001136190
NM_017773
LAX1

lymphocyte transmembrane adaptor 1

chr1_+_113064711 0.571 NM_001004440
NM_182759
FAM19A3

family with sequence similarity 19 (chemokine (C-C motif)-like), member A3

chr22_+_18388656 0.571 C22orf25
chromosome 22 open reading frame 25
chrX_+_152823722 0.570 NM_000054
NM_001146151
AVPR2

arginine vasopressin receptor 2

chr12_-_6668787 0.568 NM_001039918
NM_133476
ZNF384

zinc finger protein 384

chr1_+_24518501 0.567 NM_001195010
GRHL3
grainyhead-like 3 (Drosophila)
chr1_-_20318578 0.564 NM_012400
PLA2G2D
phospholipase A2, group IID
chr2_-_37047113 0.564 NM_003162
STRN
striatin, calmodulin binding protein
chr8_-_30826074 0.563 NM_031271
TEX15
testis expressed 15
chr16_+_2873196 0.561 NM_001142499
NM_001142500
NM_138439
FLYWCH2


FLYWCH family member 2


chr1_+_55044323 0.560 NM_001110533
NM_152607
C1orf177

chromosome 1 open reading frame 177

chr21_+_44549486 0.555 PFKL
phosphofructokinase, liver
chr1_-_19058741 0.548 NM_152232
TAS1R2
taste receptor, type 1, member 2
chr17_-_37590910 0.543 NM_001524
HCRT
hypocretin (orexin) neuropeptide precursor
chr19_+_8023887 0.540 NM_005624
CCL25
chemokine (C-C motif) ligand 25
chrX_+_105298953 0.535 NM_001171020
NM_152423
MUM1L1

melanoma associated antigen (mutated) 1-like 1

chr1_+_24518398 0.534 NM_198173
NM_198174
GRHL3

grainyhead-like 3 (Drosophila)

chr8_+_144428083 0.534 GLI4
GLI family zinc finger 4
chrX_-_130251068 0.533 NM_001170961
NM_001170962
NM_001555
NM_205833
IGSF1



immunoglobulin superfamily, member 1



chr16_-_1971180 0.526 NM_172167
NM_172168
NOXO1

NADPH oxidase organizer 1

chrX_-_8729377 0.526 NM_001171186
NM_174951
FAM9A

family with sequence similarity 9, member A

chr11_-_34336102 0.523 NM_145804
ABTB2
ankyrin repeat and BTB (POZ) domain containing 2
chr12_+_48784057 0.522 NM_005276
GPD1
glycerol-3-phosphate dehydrogenase 1 (soluble)
chrX_-_111212659 0.519 NM_012471
TRPC5
transient receptor potential cation channel, subfamily C, member 5
chr17_+_24944605 0.513 NM_152345
ANKRD13B
ankyrin repeat domain 13B
chr5_+_147775652 0.513 FBXO38
F-box protein 38
chr7_+_29840865 0.511 NM_001080529
WIPF3
WAS/WASL interacting protein family, member 3
chr2_-_73346215 0.505 FBXO41
F-box protein 41
chr12_+_54361596 0.504 NM_152637
METTL7B
methyltransferase like 7B
chr3_+_11009419 0.499 NM_003042
SLC6A1
solute carrier family 6 (neurotransmitter transporter, GABA), member 1
chr11_+_110631916 0.494 NM_198498
C11orf53
chromosome 11 open reading frame 53
chr17_-_8241868 0.491 NM_001146684
RNF222
ring finger protein 222
chr8_+_11877238 0.489 NM_001033017
DEFB135
defensin, beta 135
chr17_-_26257341 0.487 NM_024683
C17orf42
chromosome 17 open reading frame 42
chr22_+_34979118 0.484 APOL1
apolipoprotein L, 1
chr1_-_36338436 0.481 NM_005202
COL8A2
collagen, type VIII, alpha 2
chr1_-_143786993 0.480 NM_022359
PDE4DIP
phosphodiesterase 4D interacting protein
chrX_-_69186506 0.479 NM_001002254
AWAT2
acyl-CoA wax alcohol acyltransferase 2
chr19_-_53935648 0.478 NM_017805
RASIP1
Ras interacting protein 1
chrX_-_148394570 0.476 NM_000202
NM_001166550
NM_006123
IDS


iduronate 2-sulfatase


chr1_+_28458546 0.469 NM_031459
SESN2
sestrin 2
chr22_+_34979062 0.469 NM_001136540
NM_001136541
NM_003661
NM_145343
APOL1



apolipoprotein L, 1



chr7_-_99312591 0.466 NM_001005276
OR2AE1
olfactory receptor, family 2, subfamily AE, member 1
chrX_+_149364377 0.465 NM_001177466
NM_005491
MAMLD1

mastermind-like domain containing 1

chr6_+_33495824 0.460 NM_006772
SYNGAP1
synaptic Ras GTPase activating protein 1
chr6_-_31977747 0.457 NM_181842
ZBTB12
zinc finger and BTB domain containing 12
chr11_+_64737886 0.456 NM_001004326
SLC22A20
solute carrier family 22, member 20
chrX_-_130250715 0.456 NM_001170963
IGSF1
immunoglobulin superfamily, member 1
chr11_+_17714070 0.456 NM_001112741
NM_004976
KCNC1

potassium voltage-gated channel, Shaw-related subfamily, member 1

chr3_+_39484073 0.455 NM_182935
MOBP
myelin-associated oligodendrocyte basic protein
chr1_+_20385164 0.454 NM_152376
UBXN10
UBX domain protein 10
chr4_+_55218663 0.452 NM_000222
NM_001093772
KIT

v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog

chr12_+_6751930 0.451 NM_002286
LAG3
lymphocyte-activation gene 3
chrX_-_130250880 0.450 IGSF1
immunoglobulin superfamily, member 1
chr5_+_149549712 0.448 NM_014228
SLC6A7
solute carrier family 6 (neurotransmitter transporter, L-proline), member 7
chr1_+_115373937 0.447 NM_000549
TSHB
thyroid stimulating hormone, beta
chr12_-_55614311 0.446 NM_148897
SDR9C7
short chain dehydrogenase/reductase family 9C, member 7
chr10_+_104580420 0.445


chr3_-_135131207 0.444 NM_025041
C3orf36
chromosome 3 open reading frame 36
chr19_-_242335 0.443 NM_003712
NM_177526
PPAP2C

phosphatidic acid phosphatase type 2C

chr15_-_89338728 0.442 NM_003981
NM_199413
NM_199414
PRC1


protein regulator of cytokinesis 1


chrX_+_149612488 0.441 NM_003828
MTMR1
myotubularin related protein 1
chr11_+_10480891 0.440 AMPD3
adenosine monophosphate deaminase 3
chr1_+_34993234 0.440 NM_005268
GJB5
gap junction protein, beta 5, 31.1kDa
chr10_+_35524835 0.438 NM_182721
NM_182722
NM_182723
NM_182724
NM_182725
CREM




cAMP responsive element modulator




chr12_-_117026038 0.438 NM_019086
VSIG10
V-set and immunoglobulin domain containing 10
chr1_+_246682699 0.438 NM_001004136
OR2T2
olfactory receptor, family 2, subfamily T, member 2
chr5_-_139917206 0.436 SRA1
steroid receptor RNA activator 1
chr20_-_49852353 0.434 NM_020436
SALL4
sal-like 4 (Drosophila)
chr19_-_55124764 0.434 NM_016553
NUP62
nucleoporin 62kDa
chr12_-_110410730 0.433 ATXN2
ataxin 2
chr10_-_30356344 0.431 KIAA1462
KIAA1462
chr10_+_35524060 0.421 NM_182717
NM_182718
NM_182719
NM_182720
CREM



cAMP responsive element modulator



chr3_-_197549640 0.419 NM_138461
TM4SF19
transmembrane 4 L six family member 19
chr11_+_70954256 0.413 NM_001012710
KRTAP5-10
keratin associated protein 5-10
chr3_-_188903038 0.413 NM_001004312
RTP2
receptor (chemosensory) transporter protein 2
chr14_-_94053933 0.413 NM_173850
SERPINA12
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12
chr3_-_42892636 0.413 NM_004391
CYP8B1
cytochrome P450, family 8, subfamily B, polypeptide 1
chrX_+_99786044 0.409 SRPX2
sushi-repeat containing protein, X-linked 2
chrX_-_153500584 0.406 NM_001327
NM_139250
CTAG1B
CTAG1A
cancer/testis antigen 1B
cancer/testis antigen 1A
chr9_+_42707229 0.405 NM_001099279
NM_199244
FOXD4L2
FOXD4L4
forkhead box D4-like 2
forkhead box D4-like 4
chr16_+_55612125 0.404 NLRC5
NLR family, CARD domain containing 5
chr3_-_58497913 0.403 NM_003500
ACOX2
acyl-CoA oxidase 2, branched chain
chr14_-_22974707 0.401 NM_000257
MYH7
myosin, heavy chain 7, cardiac muscle, beta
chr5_+_175908948 0.400 NM_017675
CDHR2
cadherin-related family member 2
chr4_+_110968594 0.398 NM_006583
RRH
retinal pigment epithelium-derived rhodopsin homolog
chrX_-_37964924 0.398 NM_001170750
NM_001170751
NM_001170752
NM_006307
SRPX



sushi-repeat containing protein, X-linked



chrX_+_79562601 0.397 NM_152630
FAM46D
family with sequence similarity 46, member D

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.32 2.04e-02 GO:0005576 extracellular region

Nothing significant found in function category.